Can We Assess Early DNA Damage at the Molecular Scale by Radiation Track Structure Simulations? A Tetranucleosome Scenario in Geant4-DNA

Radiation track and DNA damage

radiation track and dna damage

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Radiation track and DNA damage

hisarticle provides a brief review of aspects of biophysical modelling in radiation biology. A major concern of radiation biology in the past half century has been the quantification of the health hazards of ionising radiations of different qualities and extrapolation of human cancer risks at high dose and dose rates to low dose and dose rates (UNSCEAR 1993). In the past decade with the acceler...

Investigation of the direct DNA damages irradiated by protons of different energies using geant4-DNA toolkit

Background: The total yields of direct Single-Strand Breaks (SSBs) and Double-Strand Breaks (DSBs) in proton energies varying from 0.1 to 40 MeV were calculated. While other studies in this field have not used protons with energy less than 0.5 MeV, our results show interesting and complicated behavior of these protons. Materials and Methods: The simulation has been done using the Geant4-DNA too...

Preliminary Investigation of Microdosimetric Track Structure Physics Models in Geant4-DNA and RITRACKS

The major differences between the physics models in Geant4-DNA and RITRACKS Monte Carlo packages are investigated. Proton and electron ionisation interactions and electron excitation interactions in water are investigated in the current work. While these packages use similar semiempirical physics models for inelastic cross-sections, the implementation of these models is demonstrated to be signi...